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  • Title: Melatonin does not influence the expression of c-fos in the suprachiasmatic nucleus of rats and hamsters.
    Author: Kumar V, Goguen DM, Guido ME, Rusak B.
    Journal: Brain Res Mol Brain Res; 1997 Dec 15; 52(2):242-8. PubMed ID: 9495545.
    Abstract:
    We have assessed whether melatonin can induce c-fos expression at various circadian phases, and whether melatonin can inhibit photically induced c-fos expression in the suprachiasmatic nucleus (SCN) in both rats and Syrian hamsters. Subcutaneous administration of melatonin at a dose of 100 microg/kg neither induced expression of Fos, the protein product of the c-fos proto-oncogene, nor inhibited the expression of Fos-like immunoreactivity (Fos-lir) induced by a light pulse in the SCN of rats and hamsters. In situ hybridization studies also demonstrated the absence of induction by acute melatonin treatments of c-fos mRNA in the SCN. Taken together, these results demonstrate that melatonin effects on SCN cells involve signal transduction pathways that do not include regulation of c-fos gene expression.
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