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  • Title: Plain CT findings of brain death confirmed by hollow skull sign in brain perfusion SPECT.
    Author: Yoshikai T, Tahara T, Kuroiwa T, Kato A, Uchino A, Abe M, Tabuchi K, Kudo S.
    Journal: Radiat Med; 1997; 15(6):419-24. PubMed ID: 9495795.
    Abstract:
    Computed tomographic (CT) findings of 13 patients manifesting brain death were reviewed. This diagnosis was confirmed by the so-called "hollow skull" pattern observed in brain perfusion single photon emission computed tomography (SPECT), which was performed between 4 hours before and 3 days after the CT scans, and by subsequent corporal death. The brain perfusion SPECT was performed with the intravenous administration of technetium (Tc)-99m-hexamethylpropyleneamine oxime (HMPAO) or iodine (I)-123-N-isopropyl-p-iodoamphetamine (IMP). CT scans showed diffuse cerebral edema and the loss of gray-white matter differentiation in all the cases, and transtentorial herniation in 12 patients. These CT findings were considered predictive of brain death.
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