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  • Title: Effects of GABA, glycine, picrotoxin and bicuculline methochloride on rubrospinal neurones in cats.
    Author: Altmann H, Ten Bruggencate G, Pickelmann P, Steinberg R.
    Journal: Brain Res; 1976 Jul 30; 111(2):337-45. PubMed ID: 949607.
    Abstract:
    A microelectrophoretic study was performed of the actions of GABA and glycine, and of their antagonists on rubrospinal neurones. GABA and glycine depressed antidromic and synaptic potentials, hyperpolarized the cell membrane and increased the membrane conductance. GABA was more effective than glycine. Corticorubral IPSPs and the GABA-induced membrane hyperpolarization could be reversed by intracellular application of hyperpolarizing currents. Picrotoxin and bicuculline methochloride antagonized inhibitory GABA actions and the corticorubral IPSP or the corresponding extracellular positive field potential. The results support the hypothesis that GABA is the transmitter of the corticorubral inhibition in the cat.
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