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  • Title: Circadian and circannual rhythms in the function of central 5-HT1A receptors in laboratory rats.
    Author: Nagayama H, Lu JQ.
    Journal: Psychopharmacology (Berl); 1998 Feb; 135(3):279-83. PubMed ID: 9498731.
    Abstract:
    In order to elucidate whether a circannual rhythm exists in the function of the central serotonin (5-HT) system, we examined the responsiveness of rats to a selective 5-HT1A agonist, 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT), at different hours of the day in different seasons. The results indicate that both a circadian rhythm and a circannual rhythm exist in the responsiveness. The phases of the circadian rhythm exhibit 1-year period variations, while those of the circannual rhythm exhibit 1-day period variations. These results will help to clarify the disparities among the reports on circadian and circannual rhythms in the phenomenon related to the central 5-HT system.
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