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  • Title: [Digitalis poisoning treated with a specific antidote].
    Author: Rykke EO, Bredesen JE, Stokland O, Jacobsen D.
    Journal: Tidsskr Nor Laegeforen; 1998 Jan 30; 118(3):408-10. PubMed ID: 9499730.
    Abstract:
    Toxicity by digitalis is a common problem in everyday clinical practice. In this paper three cases of severe poisoning with digitoxin with maximal S-digitoxin levels of 115, 150 and 239 nmol/l are described. All patients received specific digoxin Fab-fragment intravenously. Administration of antidotes resulted in a favourable outcome in all three patients. So far, the use of digoxin-specific antibodies has been limited to a few cases of severe intoxication where life-threatening arrhythmias and hyperkalaemia were present. We discuss whether a more liberal indication should be accepted.
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