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  • Title: [Reversal of the pressor effect of PGF2alpha in the rat (author's transl)].
    Author: Damas J.
    Journal: Experientia; 1976 Jun 15; 32(6):725-7. PubMed ID: 950019.
    Abstract:
    In normal rats, prostaglandin F2alpha is a potent vasoconstrictor. The corresponding systemic hypertension is progressively attenuated by tachyphylaxis, revealing a longlasting fall of blood pressure. Tachyphylaxis is accelerated by previous injection of arachidonic acid and bradyskinin. The vasodepressive activity of PGF2alpha is inhibited by indomethacin.
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