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  • Title: Norethisterone therapy for bleeding due to gastrointestinal telangiectases in Glanzmann's thrombasthenia.
    Author: Leach M, Makris M, Hampton KK, Preston FE.
    Journal: Br J Haematol; 1998 Mar; 100(3):594-6. PubMed ID: 9504647.
    Abstract:
    We report a case of a patient with Glanzmann's thrombasthenia and anti-GPIIb/IIIa alloantibodies who developed life-threatening and intractable bleeding from gastrointestinal telangiectatic lesions. After a period of transfusion-dependent gastrointestinal bleeding despite tranexamic acid, oral iron, omeprazole and platelet transfusions, the use of oral norethisterone produced a significant improvement with a marked reduction in her transfusion requirements.
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