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  • Title: Anti-thymocyte globulin, cyclosporin A and granulocyte colony-stimulating factor for severe aplastic anaemia complicating paediatric liver transplantation.
    Author: Hadzic N, Layton M, Heaton ND, Rela M, Baker AJ, Mieli-Vergani G.
    Journal: Eur J Pediatr; 1998 Feb; 157(2):107-8. PubMed ID: 9504782.
    Abstract:
    UNLABELLED: We describe a sustained trilineage haematopoietic response to intensified immunosuppressive therapy with anti-thymocyte globulin, cyclosporin A and recombinant human granulocyte colony-stimulating factor in a 4-year-old girl, who developed severe aplastic anaemia after orthotopic liver transplantation for fulminant liver failure induced by non A-E hepatitis. The outcome was successful and allows the following. CONCLUSION: Intense immunosuppression in combination with haemopoetic growth factors and antimicrobial prophylaxis should be considered as first line therapy in severe aplastic anaemia after orthotopic liver trans-plantation.
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