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  • Title: Low molecular weight proteins as urinary markers of aminoglycoside nephrotoxicity in man.
    Author: Valette JP, Nicot G, Charmes JP, Merle L, Benevent D, Leroux-Robert C.
    Journal: Proc Eur Dial Transplant Assoc; 1979; 16():597-602. PubMed ID: 95049.
    Abstract:
    The proteinuria of fifteen patients treated with just aminoglycoside or aminoglycoside and either penicillin or cephalosporin was studied. The proteinuria was analysed by means of immunoelectrophoresis, acetate cellulose electrophoresis, thin-layer polyacrylamide gel electrophoresis and sodium dodecylsulphate acrylamide gel electrophoresis. We observed a urinary excretion of free immunoglobulin light chains and an increased urinary excretion of lysozyme in all cases. The increase in urinary excretion of beta-2-microglobulin and retinol-binding-protein appeared only in patients treated with aminoglycoside and cephalosporin. These disturbances disappeared a few days after the treatment was discontinued.
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