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  • Title: Subcellular localization of the heparin-neutralizing factor in blood platelets.
    Author: Da Prada M, Jakábová M, Lüscher EF, Pletscher A, Richards JG.
    Journal: J Physiol; 1976 May; 257(2):495-502. PubMed ID: 950602.
    Abstract:
    1. The distribution of the heparin-neutralizing factor (platelet factor 4, PF4) in subcellular organelles of blood platelets of rabbits and man was investigated. 2. In both species the organelles storing 5-hydroxytryptamine (5-HT storage organelles) contained only trivial amounts of PF4. 3. In contrast, the content of PF4 was highest in the subcellular fractions rich in alpha-granules. 4. In conclusion, PF4 is probably localized in the alpha-granules and therefore the platelets contain at least two types of organelles (5-HT organelles and alpha-granules) capable of releasing their contents in response to the same stimuli, such as exposure to collagen, thrombin, etc.
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