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  • Title: Prevalence of HSV-2 antibodies among STD clinic patients in Tanzania.
    Author: Langeland N, Haarr L, Mhalu F.
    Journal: Int J STD AIDS; 1998 Feb; 9(2):104-7. PubMed ID: 9506376.
    Abstract:
    Patients attending a referral sexually transmissible diseases clinic at Muhimbili Medical Centre in Dar-es-Salaam during the period 1989 to 1993 were examined for herpes simplex virus type 2 (HSV-2) antibodies. An ELISA technique, using glycoprotein G of HSV-2 as antigen, was used to test 294 patients' sera. Of these, 126 sera were HSV-2 positive, while 168 were negative, yielding an overall HSV-2 prevalence of 42.9%. Sixty-three per cent of the women and 35.5% of the men were HSV-2 positive. Seropositivity rose from 8.7% in the youngest men to 61.5% in the oldest male age group, while even the youngest women aged 20 or less had an HSV-2 prevalence of 55.6%. There was a significant positive association between HIV and HSV-2 seropositivity (P=0.0006), most pronounced among the youngest women. There was no over-representation of HSV-2 positivity among patients with genital ulcer disease, indicating that other causes of this disease could be more common than HSV-2 in Tanzania. 294 blood sera were collected from 211 men and 81 women attending, for the first time, a referral sexually transmitted disease clinic at Muhimbili Medical Center in Dar-es-Salaam during 1989-93 for examination for the presence of herpes simplex virus type 2 (HSV-2) antibodies. The men's and women's mean ages were 28.2 and 24.8 years, respectively. An ELISA technique, using glycoprotein G of HSV-2 as antigen, was used to test patients' sera, of which 126 were HSV-2-positive, for an overall HSV-2 prevalence of 42.9%. 35.5% of men and 63% of women were HSV-2 positive. Seropositivity increased from 8.7% among the youngest men to 61.5% among the oldest men, while even 55.6% of the youngest women aged 20 and under were HSV-2 positive. The significant positive association between HIV and HSV-2 seropositivity was most marked among the youngest women. There was no over-representation of HSV-2 positivity among patients with genital ulcer disease.
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