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Title: Stiff-leg syndrome: a focal form of stiff-man syndrome. Author: Saiz A, Graus F, Valldeoriola F, Valls-Solé J, Tolosa E. Journal: Ann Neurol; 1998 Mar; 43(3):400-3. PubMed ID: 9506561. Abstract: We report on 2 patients who presented stiffness and spasms similar to those of stiff-man syndrome (SMS) that were limited to one leg for up to 11 years. Patients had serum glutamic acid decarboxylase (GAD) autoantibodies in high titer, clinical evidence of organ-specific autoimmunity, and electromyographic pattern of continuous motor unit activity with abnormally enhanced exteroceptive reflexes. The clinical and immunological profile suggests that this disorder may be a focal form of SMS.[Abstract] [Full Text] [Related] [New Search]