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  • Title: 2-Azabicyclo (2.2.2)octane analogues of the prodine analgetics.
    Author: Clark CR, Holbrook JM, Borne RF.
    Journal: J Med Chem; 1976 Jun; 19(6):852-4. PubMed ID: 950659.
    Abstract:
    The synthesis and analgetic activity of analogues of prodine-type analgetics in which the conformation of the piperidine ring is restricted in the boat form using the 2-azabicyclo (2.2.2)octane nucleus are reported. One of these analogues, 2-methyl-6-trans-phenyl-6-cis-propionoxy-2-azabicyclo (2.2.2)octane (3), showed significant analgetic activity (ED50 equals 3.1 mg/kg).
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