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  • Title: Pyrazolo[1,5-a]pyrido[3,4-e]pyrimidin-6-ones. II. Synthesis and in vitro antimicrobial evaluation.
    Author: Bruni F, Selleri S, Costanzo A, Guerrini G, Ciciani G, Costagli C, Sacco C, Donato R.
    Journal: Farmaco; 1997 Oct; 52(10):639-43. PubMed ID: 9507678.
    Abstract:
    A series of Pyrazolo[1,5-a]pyrido[3,4-e]pyrimidin-6-ones (4a-p) was prepared by a simple synthetic procedure based on the reaction of hydroxylamine or methoxyamine with 2,3-substituted ethyl 7-dimethylaminovinyl pyrazolo[1,5-a]pyrimidin-6-carboxylates (3a-p). The antimicrobial activity of the obtained compounds was evaluated on a series of standard strains of Gram positive, Gram negative bacteria and fungi. None of the tested compounds showed significant activity.
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