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  • Title: Age-associated mosaicism and polyploidy in Down's syndrome.
    Author: Borsatto B, Smith Mde A, Garcez EM, Peres CA.
    Journal: Mech Ageing Dev; 1998 Jan 12; 100(1):77-83. PubMed ID: 9509397.
    Abstract:
    Age-related increases in the frequencies of cells with chromosome 21 loss and of polyploid cells were documented in short-term peripheral blood lymphocyte cultures from 54 patients with Down's syndrome (DS), ages 0 to 48 years. The polyploid data, together with previous work from this laboratory with non-DS subjects, suggest that this may be a useful indicator of aging in lymphocytes.
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