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  • Title: Serum levels of human placental lactogen, pregnancy-associated plasma protein A and endometrial secretory protein PP14 in first trimester of diabetic pregnancy.
    Author: Pedersen JF, Sørensen S, Mølsted-Pedersen L.
    Journal: Acta Obstet Gynecol Scand; 1998 Feb; 77(2):155-8. PubMed ID: 9512318.
    Abstract:
    OBJECTIVE: To study maternal serum levels of human placental lactogen (hPL), pregnancy-associated plasma protein A (PAPP-A) and endometrial secretory protein PP14 (PP14) in first trimester of diabetic pregnancy. METHODS: Seventy-nine insulin-dependent diabetic women and 93 normal pregnant women had a venous blood sample drawn in weeks 8-14, ultrasound age. Serum levels were measured by radioimmunoassays and expressed in multiples of the median serum value in normal pregnancy at that ultrasound age. RESULTS: Levels of hPL were significantly lower in diabetic mothers than in controls, z'= -5.502, p<0.00001. Levels of PAPP-A were also significantly lower, z' =2.263, p=0.024, but were significantly less depressed than those of hPL, z'=2.41, p=0.015. The PP14 levels did not deviate from normal. CONCLUSION: In first trimester of diabetic pregnancy there appears to be both a more general depression of trophoblast function, and also a specific depression of the hPL release.
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