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  • Title: [Arterial infusion chemotherapy with SMANCS-Lipiodol for multiple hepatocellular carcinoma].
    Author: Takizawa K, Honda M, Obuchi M, Matsuoka S, Shima H, Uchiyama K, Hasebe S, Doai K, Satoh S, Kuniyasu Y.
    Journal: Gan To Kagaku Ryoho; 1998 Feb; 25 Suppl 1():24-9. PubMed ID: 9512683.
    Abstract:
    Fifty-five patients with hepatocellular carcinoma were treated with oily anticancer agent SMANCS dissolved in Lipiodol (SMANCS-LPD). The local response rate after the first arterial infusion in all patients was 39%, against 63% in 27 patients with Lipiodol accumulation occupying more than two thirds of tumor areas. The infusion therapy with SMANCS-LPD is adapted for a vascular-rich hepatocellular carcinoma. An infusion of 4 mg of SMANCS was ineffective for patients with tumors distributing in bilateral lobes of liver. Thus, an increase of infusion dosage or repeated infusions were recommended for such cases.
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