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  • Title: The effects of antipyretics on metabolic processes in rat liver mitochondria. Part II. The action of sodium salicylate, and pyrazolones on oxidation of alpha-ketoglutarate.
    Author: Poćwiardowska E.
    Journal: Pol J Pharmacol Pharm; 1976; 28(3):227-31. PubMed ID: 951304.
    Abstract:
    The effect of sodium salicylate (SS), phenazone (Ph), and amiphenazone (APh) on the uptake of alpha-ketoglutarate (alpha-KG) by the rat liver mitochondria was studied in vitro. The investigated antipyretics inhibited the uptake of alpha-KG in the state 3 of respiration, and significantly increased it in state 4. This results and those of the preceding paper show that alpha-KG taken up by the mitochondrial preparations in respiratory state 4 is not utilized in the oxidative processes of the respiratory chain.
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