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  • Title: A distinct region of chromosome 19p13.3 associated with the sporadic form of adenoma malignum of the uterine cervix.
    Author: Lee JY, Dong SM, Kim HS, Kim SY, Na EY, Shin MS, Lee SH, Park WS, Kim KM, Lee YS, Jang JJ, Yoo NJ.
    Journal: Cancer Res; 1998 Mar 15; 58(6):1140-3. PubMed ID: 9515797.
    Abstract:
    Adenoma malignum (AM) is known to be one of the malignant tumors that is commonly associated with Peutz-Jeghers syndrome. Recently, the genetic locus of Peutz-Jeghers syndrome was mapped to the telomeric region of chromosome 19p. We analyzed nine sporadic cases of AM with high-density loss of heterozygosity to study the region of chromosome 19p13.2-13.3 using eight microsatellite markers. Our deletion mapping data revealed a distinct region with 100% loss of heterozygosity frequency at marker D19S216. This result indicates that a putative tumor suppressor gene for AM is located at D19S216 on chromosomal band 19p13.3 and plays an important role in AM tumorigenesis.
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