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  • Title: Positive chronotropic and negative inotropic effects induced by potassium chloride in the isolated canine atrium.
    Author: Chiba S.
    Journal: Tohoku J Exp Med; 1976 May; 119(1):101-2. PubMed ID: 951701.
    Abstract:
    The effects of potassium chloride on inotropic and chronotropic activity were investigated in five isolated canine atrium preparations which were suspended in a bath and perfused with arterial blood from the carotid artery of the heparinized support dog. Potassium chloride administered into the cannulated sinus node artery in a dose range of 100 mug-1 mg produced a dose-related negative inotropic and a positive chronotropic effect. These effects were not influenced by treatment with either atropine or propranolol. From these results, it is concluded that potassium had a direct negative effect on atrial contractility and a direct positive effect on atrial rate.
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