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  • Title: [An electron microscopic study of the interaction of polarized neoplastic fibroblasts of the L line with the substrate in tissue culture].
    Author: Bragina EE.
    Journal: Tsitologiia; 1976 Mar; 18(3):344-6. PubMed ID: 951754.
    Abstract:
    Neoplastic fibroblasts of L strain were studied 24 hours after attachment to the solid artifical substrate. The cells were oriented on sections perpendicular to the substrate plane. Transformed fibroblasts moved forward 24 hours after attachment, being polarized. The main difference between normal fibroblasts studied earlier and the transformed ones was observed in the area of the spread lamellar cytoplasm on the front edge of the cell. In this place in malignant cells, a diminition of size and number of bundles of microfilaments and zones of close junction with the substrate was seen. These elements lie close to each other in normal cells, and far from each other in malignant ones. Another difference between normal and transformed cells is that the latter have many microvilli in the lower part of the surface of lamellar cytoplasm. Ultrastructural differences between normal neoplasmic cells observed in this work may be the cause of the behaviour of neoplastic cells in tissue culture.
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