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  • Title: Rapid estimation of regurgitant volume by the proximal isovelocity surface area method in mitral regurgitation: Can continuous-wave Doppler echocardiography be omitted?
    Author: Rossi A, Dujardin KS, Bailey KR, Seward JB, Enriquez-Sarano M.
    Journal: J Am Soc Echocardiogr; 1998 Feb; 11(2):138-48. PubMed ID: 9517553.
    Abstract:
    The proximal isovelocity surface area (PISA) method is accurate for quantitating mitral regurgitation but requires recording both mitral maximal and integrated jet velocities using the same continuous-wave Doppler jet signal. In 272 consecutive patients with isolated mitral regurgitation, the mean ratio of maximal to integral of velocity had a narrow range of variation (mean +/- SD, 3.25 +/- 0.47). The estimated regurgitant volume, calculated as regurgitant flow/3.25, showed an excellent correlation with reference regurgitant volumes (r = 0.96 and r = 0.97; standard error of the estimate, 11 ml; both p < 0.0001), with limited overestimation and high sensitivity and specificity for severe mitral regurgitation. The estimated regurgitant volume is a useful measurement in patients in whom the continuous-wave Doppler signal of mitral regurgitation cannot be obtained.
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