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  • Title: Double-blind study of the efficacy and safety of milnacipran and imipramine in elderly patients with major depressive episode.
    Author: Tignol J, Pujol-Domenech J, Chartres JP, Léger JM, Plétan Y, Tonelli I, Tournoux A, Pezous N.
    Journal: Acta Psychiatr Scand; 1998 Feb; 97(2):157-65. PubMed ID: 9517912.
    Abstract:
    The novel antidepressant agent milnacipran is a dual and equipotent serotonin and noradrenaline reuptake inhibitor. The aim of this double-blind study was to compare the efficacy and safety of milnacipran (50 mg twice daily) with that of imipramine (50 mg twice daily) in elderly patients with major depressive episode. A total of 219 patients were randomly assigned to 8 weeks of double-blind treatment with either milnacipran or imipramine; 72 patients withdrew from the study. At the end of treatment no significant differences were found between milnacipran and imipramine in antidepressant efficacy. A significantly greater number of side-effects, particularly anticholinergic effects, was observed in the imipramine group. Milnacipran may be preferable to imipramine in elderly depressed patients, as it provides the same antidepressant activity as imipramine with a lower incidence of side-effects, and does not impair cognitive ability.
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