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  • Title: Rapid, sensitive procedure to determine buspirone levels in rat brains using gas chromatography with nitrogen-phosphorus detection.
    Author: Lai CT, Tanay VA, Rauw GA, Bateson AN, Martin IL, Baker GB.
    Journal: J Chromatogr B Biomed Sci Appl; 1997 Dec 19; 704(1-2):175-9. PubMed ID: 9518147.
    Abstract:
    Reported here is a rapid, sensitive and relatively inexpensive procedure using gas chromatography with nitrogen-phosphorus detection (GC-NPD) to quantify buspirone levels in brains of rats. The analyte was directly extracted from brain homogenate with toluene after basification and then subjected to GC-NPD analysis using a capillary column. The calibration curves were linear over the range of 10 to 320 ng per 2 ml of brain homogenate, with typical r2 values >0.99. The assay was highly reproducible and gave peaks with excellent chromatographic properties.
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