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  • Title: Isoprinosine increases the antitumor action of interferon.
    Author: Cerutti I, Chany C, Schlumberger JF.
    Journal: Int J Immunopharmacol; 1979; 1(1):59-63. PubMed ID: 95187.
    Abstract:
    The association of relatively low doses of interferon with an immunostimulant, isoprinosine, enhanced the antitumor effect of interferon. Each mouse was inoculated with 10(6) Crocker Tumor 180/TG cells. The best results were obtained when both interferon and isoprinosine were injected three times a week for 1 month. Under these conditions, the mean survival time increased from 26 days in the controls to 45 days in the interferon-treated group to 64 days when both agents were used. Isoprinosine alone had no effect. The final survival rate increased from 1 mouse out of 50 mice in the control group to 10 mice out of 50 in the interferon-treated groups and to 25 mice out of 50 with the combined treatment.
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