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  • Title: The hypertension of long-term hemodialysis patients: studies with an angiotensin II antagonist (P113).
    Author: Mimran A, Shaldon S, Mathieu MN, Polito C, Barjon P, Mion C.
    Journal: Trans Am Soc Artif Intern Organs; 1976; 22():9-13. PubMed ID: 951896.
    Abstract:
    1. A P113 Saralasin infusion test was performed in 10 patients on long-term regular hemodialysis. Six patients were considered to have hypertension resistant to dialysis treatment and 4 had their arterial pressure controlled by dialysis. 2. Five out of 6 resistant and 3 out of 4 responsive patients had a positive response to Saralasin associated with a normalization of diastolic arterial pressure. 3. The value of the Saralasin infusion test to pre-select the patients for bilateral nephrectomy is discussed and it is felt that a negative test may be of more value in encouraging more aggressive ultrafiltration in hypertension apparently resistant to dialysis therapy.
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