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  • Title: Assessing the relationship between maternal cocaine use and abruptio placentae.
    Author: Hulse GK, Milne E, English DR, Holman CD.
    Journal: Addiction; 1997 Nov; 92(11):1547-51. PubMed ID: 9519496.
    Abstract:
    Abruptio placentae during pregnancy can result in significant morbidity and mortality to both mother and infant. A comprehensive literature search of publications from 1966 to April 1995 identified 11 studies on the association between maternal cocaine use and abruptio placentae. Their results were combined in a meta-analysis. The pooled odds ratio for abruptio placentae and maternal cocaine use was 3.92 (95% confidence interval 2.77-5.46). The strength and consistency of the association, its biological plausibility and the results of experimental studies in animals all suggest that cocaine use during pregnancy causes abruptio placentae.
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