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  • Title: Sarcolemmal defect and subsarcolemmal lesion in a patient with gamma-sarcoglycan deficiency.
    Author: Li M, Dickson DW, Spiro AJ.
    Journal: Neurology; 1998 Mar; 50(3):807-9. PubMed ID: 9521284.
    Abstract:
    We report a case of gamma-sarcoglycanopathy with sarcolemmal defects and subsarcolemmal lesions indistinguishable from those in Duchenne muscular dystrophy. Both disorders share certain ultrastructure features that suggest a common pathogenesis related to primary deficiency of transmembrane glycoproteins (e.g., sarcoglycans) or deficiency in dystrophin, which produces a secondary deficiency in sarcoglycans. The lack of transmembrane glycoproteins may contribute to membrane lesions and associated muscle fiber degeneration and necrosis.
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