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  • Title: Hirunorms, novel hirudin-like direct thrombin inhibitors.
    Author: Cappiello M, Vilardo PG, Del Corso A, Mura U.
    Journal: Gen Pharmacol; 1998 Apr; 30(4):565-8. PubMed ID: 9522176.
    Abstract:
    1. Hirunorms are new synthetic peptides designed to interact with thrombin in a similar way to the natural inhibitor hirudin. 2. Hirunorms are specific and efficient in vitro inhibitors of thrombin activity. 3. Hirunorms are potent anticoagulant and antithrombotic agents in in vivo experimental models devoid of hemorrhagic effects at doses that are active in preventing thrombosis.
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