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  • Title: Cyclic changes of cervical mucus enzymes related to the time of ovulation. I. Alkaline phosphatase.
    Author: Moghissi KS, Syner FN, Borin B.
    Journal: Am J Obstet Gynecol; 1976 Aug 15; 125(8):1044-8. PubMed ID: 952301.
    Abstract:
    The concentration of alkaline phosphatase in cervical mucus was serially determined during a menstrual cycle in five normal ovulatory women and correlated with the time of ovulation as monitored by the basal body temperature and radioimmunoassay of serum lutenizing hormone (LH), progesterone, and estradiol. The activity of alkaline phosphatase decreased significantly at midcycle just prior to the LH surge and began to rise after ovulation. Self-detection of cervical mucus alkaline phosphatase may provide a practical method of ovulation prediction. The concentration of alkaline phosphatase in cervical mucus was determined during a menstrual cycle and related to the time of ovualtion. Blood samples and cervical mucus were obtained from 5 normal ovulatory women every 2 days before cycle Day 10 and after Day 20 and daily in the midcycle (Days 10-20). All cycles were presumed to be ovulatory on the basis of biphasic basal body temperature and luteinizing hormone (LH), estradiol and progesterone assays. Alkaline phosphatase concentration decreased significantly (p = .03) at midcycle just prior to the LH surge and began to rise after ovulation. It is suggested that combined with the perception of mucorrhea, self-detection of cervical mucus alkaline phosphatase may provide an accurate method of ovulation prediction.
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