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  • Title: Consequences of aging on mitochondrial respiratory chain enzymes in cultured human fibroblasts treated with ascorbate.
    Author: Sharma P, Rupar CA, Rip JW.
    Journal: Gerontology; 1998; 44(2):78-84. PubMed ID: 9523218.
    Abstract:
    The activities of mitochondrial respiratory chain enzymes with and without ascorbate pretreatment were assayed in 10- to 20-week-old cultures of human fibroblasts. Aging was associated with a significant loss of respiratory chain enzyme activities. The presence of ascorbate in the medium reduced the rate of loss of these enzymes. Free radical-mediated injuries may also contribute to aging since the changes seen in respiratory chain enzyme activities are similar to those seen in oxidatively stressed cells. This study demonstrates an age-related decline in mitochondrial respiratory chain activity as well as a protective role for ascorbate in aging.
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