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  • Title: [Delayed-type hypersensitivity induced by digestive immunization and suppression of this induction by antigen-antibody complexes (author's transl)].
    Author: André C, André F.
    Journal: Ann Immunol (Paris); 1976; 127(1):43-7. PubMed ID: 952497.
    Abstract:
    BALB/c mice were immunized by intragastric administration of sheep red blood cells or horse red blood cells repeated daily for 4 days. The immunized animals when skin tested with an urea extract of the corresponding antigen showed a delayed-type hypersensitivity reaction. This reaction was observed for 4 weeks after the immunization. This result demonstrates that digestive immunization may induce cellular immunity. When serum from intragastrically immunised mice containing antigen-antibody complexes was administered intraperitoneally 8 hours before the onset of digestive immunization, the subsequent delayed-type hypersensitivity reaction was suppressed or considerably depressed.
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