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Title: Endothelin-converting enzyme: its functional aspect. Author: Gomazkov OA. Journal: Biochemistry (Mosc); 1998 Feb; 63(2):125-32. PubMed ID: 9526103. Abstract: The system of endothelin peptides and their structure, biological activity, and role in physiological and pathological processes are reviewed with emphasis on endothelin-converting enzyme (ECE), which catalyzes the terminal processing of endothelin. Molecular specificity, structure, isoforms, physicochemical characteristics, substrate preference, and tissue localization characterize this enzyme as a novel and highly important metalloendopeptidase. The role of ECE in pathological processes and data on inhibitors of the enzyme which can have medical implication are summarized.[Abstract] [Full Text] [Related] [New Search]