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  • Title: Quantitation of ineffective erythropoiesis from the incorporation of [15N] delta-aminolaevulinic acid and [15N] glycine into early labelled bilirubin. I. Normal subjects.
    Author: Samson D, Halliday D, Nicholson DC, Chanarin I.
    Journal: Br J Haematol; 1976 Sep; 34(1):33-44. PubMed ID: 952766.
    Abstract:
    The incorporation of [15N] glycine into early labelled bilirubin and haemoglobin haem was measured in four haematologically normal subjects, using the clearance of [14C] bilirubin to measure total bilirubin production rate. Hepatic haem turnover was calculated from the incorporation of [15N]=sigma-aminolaevulinic acid into early labelled bilirubin. From the exprimental data previously published data in normal subjects a method is derived for the quantitation of ineffective erythropoiesis which can be applied to similar studies in patients with haematological disorders.
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