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  • Title: Alterations in the GyrA subunit of DNA gyrase and the ParC subunit of DNA topoisomerase IV associated with quinolone resistance in Enterococcus faecalis.
    Author: Kanematsu E, Deguchi T, Yasuda M, Kawamura T, Nishino Y, Kawada Y.
    Journal: Antimicrob Agents Chemother; 1998 Feb; 42(2):433-5. PubMed ID: 9527801.
    Abstract:
    The gyrA and parC genes of 31 clinical isolates of Enterococcus faecalis, including fluoroquinolone-resistant isolates, were partially sequenced and analyzed for target alterations. Topoisomerase IV may be a primary target in E. faecalis, but high-level fluoroquinolone resistance was associated with simultaneous alterations in both GyrA and ParC.
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