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  • Title: The effect of hashish compounds on pphospholipid phase transition.
    Author: Bach D, Raz A, Goldman R.
    Journal: Biochim Biophys Acta; 1976 Jul 15; 436(4):889-94. PubMed ID: 952922.
    Abstract:
    The interaction of hashish compounds, delta 1-tetrahydrocannabinol and cannabidiol, with dipalmitoyl phosphatidylcholine was investigated using differential scanning calorimetry. Both drugs affect the transition of dipalmitoyl phosphatidylcholine from the gel to liquid crystalline state, decreasing both the melting temperature and the enthalpy of melting. At a drug to dipalmitoyl phosphatidylcholine ratio of approx. 1:5, two peaks appear in the transition profile, suggesting a phase separation in the drug dipalmitoyl phosphatidylcholine mixture.
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