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  • Title: Mechanism of activation and function of protein kinase B.
    Author: Alessi DR, Cohen P.
    Journal: Curr Opin Genet Dev; 1998 Feb; 8(1):55-62. PubMed ID: 9529606.
    Abstract:
    The past year has seen significant advances in our understanding of how protein kinase B (PKB) is activated and of the central role it plays in insulin signalling and in mediating the protective effects of survival factors against apoptosis. The highlights include the discovery of a protein kinase required for the 3-phosphoinositide-dependent activation of PKB and the identification of several physiological substrates for PKB.
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