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  • Title: Isolated ataxia as an idiosyncratic side-effect under gabapentin.
    Author: Steinhoff BJ, Herrendorf G, Bittermann HJ, Kurth C.
    Journal: Seizure; 1997 Dec; 6(6):503-4. PubMed ID: 9530950.
    Abstract:
    Gabapentin has been accepted worldwide as a novel antiepileptic drug with a favourable tolerability profile. However, movement disorders have been reported previously as rare side-effects in individual patients. We report on two patients who developed isolated severe ataxia under low-dose gabapentin which resolved abruptly after discontinuation of the drug. This side-effect probably resembled a rare idiosyncratic adverse reaction. We propose the gabapentin-specific neuronal binding site which has a high density in the cerebellum as a possible mechanism of action and suggest that the initiation of gabapentin requires caution if pre-existing cerebellar function impairment is evident.
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