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  • Title: Cytotoxic substances produced by a fungal strain from a sponge: physico-chemical properties and structures.
    Author: Amagata T, Usami Y, Minoura K, Ito T, Numata A.
    Journal: J Antibiot (Tokyo); 1998 Jan; 51(1):33-40. PubMed ID: 9531985.
    Abstract:
    Five novel metabolites, trichodenones A-C (1-3), harzialactone A (4) and B (5), have been isolated together with known R-mevalonolactone (6) from the culture broth of a strain of Trichoderma harzianum OUPS-N115 originally separated from the sponge Halichondria okadai. Their structures have been elucidated by spectral evidence. Among them, 1-3 exhibited significant cytotoxicity against cultured P388 cells.
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