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  • Title: [Antioxidant probucol: effects on free radical lipid peroxidation, blood rheology and course of angina pectoris].
    Author: Zakirova AN, Shamaev AG, Mirionkova NA.
    Journal: Ter Arkh; 1998; 70(1):29-32. PubMed ID: 9532648.
    Abstract:
    AIM: Study of the effect of antioxidant probucol on free-radical lipid peroxidation, blood rheology, and course of angina pectoris in coronary patients. MATERIALS AND METHODS: The above parameters and clinical hemodynamic values were monitored over the course of probucol therapy in 48 men (mean age 54.8 +/- 1.3 years) with coronary disease and angina of effort of the II-III functional class. RESULTS: Long therapy with probucol effectively inhibited free-radical lipid peroxidation, normalized lipid spectrum of the blood, and had a favorable impact on the course of angina pectoris. CONCLUSION: Probucol stabilizes the structure and function of red cells and platelets in coronary patients.
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