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  • Title: [Effect of striatectomy on the course of corazole seizures in rats].
    Author: Avakian RM.
    Journal: Biull Eksp Biol Med; 1976 Mar; 81(3):316-9. PubMed ID: 953278.
    Abstract:
    Behaviouristic and EEG-manifestations of pentylentetrazol convulsions were studied in unrestrained rats with preliminarily destroyed striatum. The operation caused no significant disturbance of the appearance of the spike-wave activity, but sharply inhibited provocation of myoclonic and their change into tonico-clonic convulsions. Besides, there was an increase in the threshold, the duration and the severity of the attack; an epileptic status was even observed in 50% of these rats. Striatectomy eliminated the action of catecholaminergic agents (apomorphine, DOPA, haloperidol, chlorpromazine) on the thresholds of myclonic jerks and the attack.
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