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  • Title: [Brucellosis protective antigen, its chemical and immunobiological characteristics].
    Author: Vershilova PA, Dranovskaia EA.
    Journal: Biull Eksp Biol Med; 1976 Mar; 81(3):333-5. PubMed ID: 953283.
    Abstract:
    The data on brucella nontoxic protective antigen without any sensitizing properties isolated from the cell wall of brucella are presented. The antigen had a marked protective effect against the experimental infection for 3-4 months after a single immunization of guinea pigs.Molecular heterogeneity of the antigen, which is mainly a protein-polysaccharide complex, is given. High- and low-molecular fractions detected by gel filtration technique differed according to the chemical and immunobiological characteristics. The high-molecular fraction of the antigen was found to be highly immunogenic and serologically active.
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