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  • Title: Platelet aggregation and lipoprotein levels in a patient with familial hypercholesterolemia after selective LDL-apheresis.
    Author: Pares MN, D'Amico EA, Kutner JM, Chamone Dde A, Bydlowski SP.
    Journal: Sao Paulo Med J; 1997; 115(3):1448-51. PubMed ID: 9532848.
    Abstract:
    Platelet aggregation was studied in a patient with familial hypercholesterolemia immediately after apheresis selective for low-density lipoprotein (LDL), a lipid-lowering procedure. This treatment reduced plasmatic levels of total and LDL-cholesterol, apo B, and triglyceride. Increased platelet aggregation was reduced immediately after the apheresis in whole blood as well as in platelet-rich plasma. However, aggregation in washed platelets remained unchanged after LDL-apheresis. In conclusion, in this patient reduction of LDL-cholesterol improved platelet function in the very short term.
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