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  • Title: [Combination of cyclosporin and ketoconazole in immunosuppression schemes in patients with transplanted kidney].
    Author: Treĭvish VS, Shoĭkhet IN, Ankova EV.
    Journal: Klin Med (Mosk); 1998; 76(1):40-2. PubMed ID: 9532915.
    Abstract:
    Ketoconazole was used as an adjuvant to conventional 3-component immunosuppression in 56 patients with transplanted kidney. While receiving ketoconazole postoperative patients can be given reduced doses of cyclosporin (1.5-2 times). Long after the operation cyclosporin doses can be reduced 3-4-fold. Acute rejection occurred less frequently. This means that reduced cumulative steroid dose is needed for management of the rejection. In the dose above 100 mg/day, ketoconazole is able to enhance nephrotoxic effect of cyclosporin. A complication--acute renal dysfunction--is attributed to iatrogenic hypoaldosteronism induced by combination of large-dose cyclosporin + ketoconazole.
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