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  • Title: [Enhancement of the immune response following immunization with L1210 cells preliminarily incubated with interferon].
    Author: Skurkovich SV, Kalinina IA, Eremkina EI, Bulycheva TI.
    Journal: Biull Eksp Biol Med; 1976 Jun; 81(6):706-7. PubMed ID: 953308.
    Abstract:
    A single intraperitioneal injection of L 1210 cells preincubated in interferon or in "false interferon" was given to mice. These mice were sacrificed on the 10th day, and cytotoxicity of the sera against the L 1210 leukemic cells vas determined in the microcytotoxic test (modification of Terasaki's method). Leukemic cells treated with interferon before the immunization caused a more pronounced immune response in comparison with the cells treated under the same conditions with "false interferon". By the results of cytotoxic reaction immune response was enhanced 2-4-fold.
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