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  • Title: [Effect of a lysosome triton WR 1339 load on distribution of C14-albumin in the livers of rats with chronic hepatitis].
    Author: Korolenko TA, Titova VG.
    Journal: Biull Eksp Biol Med; 1976 Jul; 82(7):816-9. PubMed ID: 953340.
    Abstract:
    A possible mechanism of the protective effect of Triton WR1339 during chronic CC14-hepatitis was considered. Supposing that the improvement of the process was due to the intensification of the lysosome heterophage function the authors studied the intensity of the C14-albumin uptake by the liver and its subcellular distribution in the liver of rats in the administration of the detergent to the animals with chronic CCI4-hepatitis, Preliminary administration of the detergent failed to influence the intensity of C14-albumin uptake; subsequent administration of triton WR1339 to rats with toxic hepatitis decrease the protein uptake which reached the values in intact rats. In chronic hepatitis C14-albumin was concentrated in the lysosome fraction. Administration of trition WR1339 to CCI4-treated animals was not accompanied by any coincidence in the peaks of labeled protein and lysosome enzymes. The selective participation of lysosomes of the Kupffer cells providing a more rapid restoration of the liver in chronic hepatitis is discussed.
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