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  • Title: Effects of fractionated irradiation on mouse lung and a phenomenon of slow repair.
    Author: Field SB, Hornsey S, Kutsutani Y.
    Journal: Br J Radiol; 1976 Aug; 49(584):700-7. PubMed ID: 953389.
    Abstract:
    The LD/50 between 40 and 180 days after irradiation of the thorax has been taken as a measure of lung damage in mice. The method has been used to derive the relationship between total dose, number of fractions (N) and overall treatment time (T). For X rays the results fit an Ellis type of relationship, i.e. total dose alphaN0-25 T0-07. This only applies for more than 8 fractions, below which N0-39 becomes a good fit to the results. For neutrons, the best fit is total dose alphaT0-07. Various possible explanations for the T factor are discussed, but for lung damage we attribute it to a slow repair process which possibly may only be observed in slowly proliferating tissues. Slow repair is about 100 times less rapid than Elkind-type of repair of sublethal damage and whereas Elkind repair is greatly reduced for irradiation with fast neutrons, relative to X rays, slow repair is not.
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