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  • Title: Requirements for muscle relaxation in Friedreich's ataxia.
    Author: Mouloudi H, Katsanoulas C, Frantzeskos G.
    Journal: Anaesthesia; 1998 Feb; 53(2):177-80. PubMed ID: 9534643.
    Abstract:
    Friedreich's ataxia is an inherited disorder of the nervous system, requiring special care during anaesthesia, because of increased sensitivity to muscle relaxants. We report a case of Friedreich's ataxia in a 31-year-old woman, anaesthetised on two occasions, for tendinoplasty and pes cavus repair. Atracurium was used for neuromuscular blockade and monitored by a train-of-four twitch technique. The patient's response was normal. She returned to adequate spontaneous breathing within 20 min of the last dose of the muscle relaxant without need for anticholinesterase administration. When neuromuscular function is monitored, normal doses of muscle relaxant can safely be used in these patients.
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