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  • Title: Pseudomembraneous clostridium after autologous bone marrow transplantation.
    Author: Kavan P, Sochor M, Nyc O, Lochmann O, Koutecky J, Skala PJ, McClain LK.
    Journal: Bone Marrow Transplant; 1998 Mar; 21(5):521-3. PubMed ID: 9535046.
    Abstract:
    Clostridium difficile (C. difficile) pseudomembraneous colitis was diagnosed in a 13-year-old boy with Hodgkin's disease 3 months after autologous bone marrow transplantation. Hematopoiesis was fully reconstituted at the time. C. difficile infection occurred after gall bladder empyema had been treated conservatively with i.v. antibiotics and prophylactic 4-week administration of oral amoxicillin. C. difficile colitis was diagnosed early and intensive supportive therapy combined with administration of i.v. and subsequently oral vancomycin therapy failed. It is a phenomenon rarely seen and successful eradication of the clostridium infection was only achieved by a combination of higher dose vancomycin with metronidazole. During the post-colitis recovery the patient experienced a relapse of Hodgkin's disease and died following further surgical intervention 137 days post-transplantation.
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