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  • Title: Reduction of 13-hydroperoxy-9,11-octadecadienoic acid by dopamine-melanin.
    Author: Stepień K, Zajdel A, Swierczek G, Wilczok A, Wilczok T.
    Journal: Biochem Biophys Res Commun; 1998 Mar 27; 244(3):781-4. PubMed ID: 9535742.
    Abstract:
    The effect of dopamine-melanin (DA-melanin), synthetic model of neuromelanin, on the stability of 13-hydroperoxyoctadecadienoic acid (13-HPODE) has been investigated using a reverse-phase high-performance liquid chromatography (HPLC) with UV detection. It was found that DA-melanin effectively accelerated the decomposition of 13-HPODE, both in the absence and in the presence of ferrous ions. The disappearance of 13-HPODE was accompanied by the formation of 13-hydroxyoctadecadienoic acid (13-HODE). The results obtained indicate that DA-melanin is able to reduce linoleic acid hydroperoxide to its stable hydroxyl derivative. The fatty acid hydroperoxide-reducing ability of DA-melanin appears to play an important role in the antioxidative activity of neuromelanin in the process of lipid peroxidation.
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